KMID : 1135520170130060621
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Korean Journal of Exercise Rehabilitation 2017 Volume.13 No. 6 p.621 ~ p.626
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Role of transforming growth factor-¥â in muscle damage and regeneration: focused on eccentric muscle contraction
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Kim Joo-Young
Lee Joo-Hyung
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Abstract
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High-intensity eccentric muscle contraction induces muscle damage. Damaged muscles recover through different processes, including degeneration, inflammation, regeneration, and fibrosis; some of these processes are mediated through the actions of cytokines. The transforming growth factor-beta (TGF-¥â) is one such cytokine involved in muscle recovery and repair. In this regard, TGF-¥â regulates the skeletal muscle inflammatory response, inhibits muscle regeneration, regulates extracellular matrix remodeling, and promotes fibrosis. Although some studies have suggested that inhibition of TGF-¥â after muscle damage promotes muscle regeneration and recovery, other studies have noted that TGF-¥â inhibition actually reduces muscle strength because it leads to incomplete muscle regeneration. Despite the importance of TGF-¥â in the repair of damaged muscles, most studies have focused on examining its role in muscle diseases such as chronic inflammatory diseases or Duchenne¡¯s muscular dystrophy. Here, we have reviewed the existing literature for examining the role of TGF-¥â in muscle damage and regeneration after eccentric muscle contraction.
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KEYWORD
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Eccentric muscle contraction, Muscle damage, Muscle regeneration, Transforming growth factor-¥â
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